Arrhythmias & electrophysiologyCohort study
Safety and Outcomes of Concomitant Left Atrial Appendage Occlusion and Atrial Fibrillation Ablation
- retrospective cohort study
- 1:1 propensity score matching
- TriNetX U.S. Collaborative Network
Authors' conclusion
In this large, propensity-matched analysis, concomitant AF ablation at the time of LAAO was not associated with increased early or 1-year complications, supporting the safety of a combined approach in appropriately selected patients.
Study context
- Population
- Adults (≥18 years) with atrial fibrillation (AF) who underwent percutaneous left atrial appendage occlusion (LAAO) between January 2015 and February 2026patients in each group after propensity score matching
- Participants
- 1,899 adults
- Exposure
- concomitant AF ablation plus LAAO vs LAAO alone
- Concomitant AF ablation plus LAAOn = 1,899
- LAAO alonen = 1,899reference
Main finding
Mortality · 90 days
Hazard ratio
1.00
95% CI 0.43–2.32
By group
Concomitant AF ablation plus LAAO vs LAAO alone
HR 1.00 (95% CI 0.43–2.32)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Concomitant AF ablation plus LAAO | LAAO alone | HR (95% CI) | |
|---|---|---|---|---|
| Mortality · 1 year · propensity score matched | 1.4% | 1.5% | 0.97 (0.58–1.63) | |
| 0.512Hazard ratio (log scale) |
Stroke, device leak, device-related thrombus · 90 days and 1 year
- Rates comparable between groups at 90 days, with no differences observed at 1 year
Baseline characteristics
- Well balanced after matching
Original publication
Safety and Outcomes of Concomitant Left Atrial Appendage Occlusion and Atrial Fibrillation Ablation. JACC Adv. Published 11 June 2026. doi:10.1016/j.jacadv.2026.102870
Summarised from the published abstract; every number is checked against it