Arrhythmias & electrophysiologyCohort study
Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study
- Multicentre retrospective registry study
- post-approval
Authors' conclusion
Taken together, these data indicate that PFA demonstrates a favorable safety profile by avoiding much of the collateral damage seen with conventional thermal ablation.
Study context
- Population
- Patients with atrial fibrillation (AF) undergoing post-approval pulsed field ablation (PFA) (mean age 64, 34.7% female, 57.8% paroxysmal AF, 35.2% persistent AF)106 of 116 centres
- Participants
- 17,642 patients
- Outcome
- Safety of PFA (complications)
Main finding
As reported in the abstract
Major complications
Major complications
~1% (173 of 17,642)
Pericardial tamponade
0.36%; 63 of 17,642
Vascular events
0.30%; 53 of 17,642
Observational data: associations, not effects.
Original publication
Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study. Nat Med. Published 8 July 2024. doi:10.1038/s41591-024-03114-3
Summarised from the published abstract; every number is checked against it