Randomised controlled trial
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial
- Cluster-randomised controlled trial
- 2 × 2 factorial
Authors' conclusion
The results of this trial indicate that use of salt substitute, but not efforts to restrict salt supply, may achieve blood pressure lowering and deliver health benefits to residents of elderly care facilities in China.
Study context
- Population
- Adults aged 55 years or older in 48 residential elderly care facilities in China48 facilities
- Participants
- 1,612 adults
- Comparison
- Salt substitute vs Usual salt
- Primary endpoint
- Systolic blood pressure
Primary result
SBP
Difference
−7.1 mmHg
95% CI −10.5 to −3.8
Salt substitute vs Usual salt
difference −7.1 mmHg (95% CI −10.5 to −3.8)
As reported in the abstract
Further findings
| Outcome | difference (mmHg) (95% CI) | |
|---|---|---|
| DBP | −1.9 (−3.6 to −0.2) | |
| −4−202Difference, mmHg (linear scale) |
| Outcome | HR (95% CI) | |
|---|---|---|
| CV events | 0.60 (0.38–0.96) | |
| Total mortality | 0.84 (0.63–1.13) | |
| 0.20.5125Hazard ratio (log scale) |
Salt restriction, all outcomes
- Salt restriction had no effect on any study outcome
Original publication
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial. Nat Med. Published 13 April 2023. doi:10.1038/s41591-023-02286-8
Summarised from the published abstract; every number is checked against it