Arrhythmias & electrophysiologyCohort study
Secondary tricuspid regurgitation: incidence, types, and outcomes in atrial fibrillation vs. sinus rhythm
- Cohort study
Authors' conclusion
New-onset AFib vs. SR conferred a higher risk of the individual TR types related to sequelae of AFib and higher pacemaker implantation rates, although the distribution of TR types was similar. Secondary TR was universally associated with increased mortality.
Study context
- Population
- Adults without structural heart disease or ≥ moderate tricuspid regurgitation (TR) at baseline, with and without new-onset AF
- Participants
- 1,359 vs 20,438
- Exposure
- New-onset AF vs sinus rhythm
- Atrial fibrillation (AFib)n = 1,359
- Sinus rhythm (SR)n = 20,438reference
- Outcome
- Incidence, types and outcomes of ≥ moderate tricuspid regurgitation
Main finding
As reported in the abstract
Development of ≥ moderate TR
AFib
109
events
SR
378
events
Observational data: associations, not effects.
Further findings
Pacemaker implantation rate
P < 0.001
Right atrial size
P < 0.001
Pulmonary pressure
P < 0.001
All-cause mortality by TR type
- All types of secondary TR associated with all-cause mortality, highest in PH-TR and left ventricular (LV) dysfunction-TR
Original publication
Secondary tricuspid regurgitation: incidence, types, and outcomes in atrial fibrillation vs. sinus rhythm. Eur Heart J. Published 2 July 2024. doi:10.1093/eurheartj/ehae346
Summarised from the published abstract; every number is checked against it