Heart failure & cardiomyopathiesResearch article
Selection and Interpretation of Molecular Diagnostics in Heart Transplantation
- Narrative review
Study context
- Population
- Heart transplant recipients, including pediatric and Black patients
Main finding
As reported in the abstract
Diagnostic modalities after heart transplant (biomarker and immunologic tests for posttransplant complications)
- Circulating biomarkers and molecular diagnostics have shown substantial predictive value in rejection monitoring
- Genomic (cell-free DNA), transcriptomic (mRNA and microRNA profiling) and proteomic methods evaluated with varying levels of evidence
- Immunogenetics has enhanced understanding of antibody-mediated rejection, associated graft dysfunction and death
Original publication
Selection and Interpretation of Molecular Diagnostics in Heart Transplantation. Circulation. Published 21 August 2023. doi:10.1161/circulationaha.123.062847
Summarised from the published abstract; every number is checked against it