Prevention & lipidsCohort study
Self-rated physical fitness predicts cardiovascular and all-cause mortality—implications for clinical decision-making
- Prospective cohort study
Authors' conclusion
Our research shows that SRPF is a strong predictor of overall and cardiovascular mortality for individuals with and without CAD.
Study context
- Population
- Participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study
- Participants
- 3,248 participants
- Exposure
- Higher vs lower self-reported physical fitness classes
- Outcome
- All-cause and CV mortality
- Follow-up
- Mean 9.9 years
Main finding
CV mortality
Hazard ratio
0.14
95% CI 0.08–0.24
Highest SRPF class vs Lowest SRPF class
HR 0.14 (95% CI 0.08–0.24)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mortality by coronary artery disease (CAD) status (subgroup)
- Similar results with angiographically documented CAD (n = 2583, 78%) and without CAD (n = 733; 22%)
Cardiometabolic and inflammatory markers
- Higher self-reported physical fitness (SRPF) associated with higher apolipoprotein A-2 and HDL-C
- P < 0.001
- Higher SRPF associated with significantly lower SBP, resting heart rate, haemoglobin A1c (HbA1c), fasting glucose, serum uric acid, hs-CRP, interleukin-6 and serum amyloid A
Original publication
Self-rated physical fitness predicts cardiovascular and all-cause mortality—implications for clinical decision-making. Eur J Prev Cardiol. Published 18 March 2025. doi:10.1093/eurjpc/zwaf154
Summarised from the published abstract; every number is checked against it