Heart failure & cardiomyopathies
Semaglutide in Patients With Obesity and Heart Failure Across Mildly Reduced or Preserved Ejection Fraction
Authors' conclusion
In patients with HFpEF and obesity, semaglutide 2.4 mg improved symptoms, physical limitations, and exercise function, and reduced inflammation and body weight to a similar extent across LVEF categories.
Study context
- Population
- Patients with the obesity phenotype of HF with preserved ejection fraction (HFpEF), categorised by left ventricular ejection fraction (LVEF) 45%–49%, 50%–59%, ≥60%categorised by LVEF 45%–49% 85 · 50%–59% 215 · ≥60% 229
- Participants
- 529 patients
- Comparison
- Semaglutide vs placebo across baseline LVEF strata
- Semaglutiden = 263
- Placebon = 266reference
- Primary endpoint
- Dual primary endpoints: KCCQ Clinical Summary Score and body weight
- Follow-up
- 52 weeks
Primary result
As reported in the abstract
Semaglutide vs PlaceboEstimated treatment difference, points (95% CI)P value
KCCQ-CSS, EF 45%-49%
5.0(−2.7 to 12.8)
KCCQ-CSS, EF 50%-59%
9.8(5.0–14.6)
KCCQ-CSS, EF ≥60%
7.4(2.8–12.0)
P = 0.56for interactionSemaglutide vs PlaceboEstimated treatment difference (95% CI)P value
Body weight, EF 45%-49%
−7.6(−10.7 to −4.4)
Body weight, EF 50%-59%
−10.6(−12.6 to −8.6)
Body weight, EF ≥60%
−11.9(−13.8 to −9.9)
P = 0.08for interactionSecondary outcomes
Confirmatory secondary and exploratory endpoints by LVEF category
- LVEF did not influence benefit on 6-minute walk distance
- P for interaction = 0.19
- LVEF did not influence benefit on hierarchical composite endpoint
- P for interaction = 0.43
- LVEF did not influence benefit on hs-CRP
- P for interaction = 0.26
- LVEF did not influence benefit on NT-proBNP (exploratory)
- P for interaction = 0.96
Safety
Tolerability
- Semaglutide was well-tolerated across LVEF categories
Original publication
Semaglutide in Patients With Obesity and Heart Failure Across Mildly Reduced or Preserved Ejection Fraction. J Am Coll Cardiol. Published 8 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →