Coronary disease & ACSCohort study
Serial troponin-I and long-term outcomes in subjects with suspected acute coronary syndrome
- Retrospective cohort study
- Danish national registries
- standardized risks
Authors' conclusion
Among individuals with suspected ACS, those with a persistently elevated hsTnI concentration consistently had the highest risk of death. In subjects with two normal hsTnI concentrations, mortality was very low and not affected by the magnitude of change between measurements.
Study context
- Population
- Individuals with suspected acute coronary syndrome (ACS) with two high-sensitivity troponin-I (hsTnI) measurements 1–7 h apart during a first-time hospitalization for MI, unstable angina, observation for suspected MI or chest pain, Denmark, 2012–2019
- Participants
- 20,609 individuals
- Exposure
- hsTnI concentration patterns and magnitude of change
- Outcome
- All-cause mortality (standardized risk of death)
- Follow-up
- 0-30 days and 31-365 days
Main finding
As reported in the abstract
Standardized risk of death
| Outcome | Normal | Rising | Persistently elevated | Falling |
|---|---|---|---|---|
| 0-30 days | 0.5% | Not reported in the abstract | 8.0% | Not reported in the abstract |
| 31-365 days | 2.6% | Not reported in the abstract | 11.1% | Not reported in the abstract |
Observational data: associations, not effects.
Further findings
| Outcome | >50% rise | Less pronounced rise |
|---|---|---|
| 30-day mortality, rising pattern, by magnitude of rise (subgroup) | 2.2% | <0.1% |
Effect of relative hsTnI change (normal and persistently elevated patterns)
- Relative hsTnI change did not clearly affect mortality risk
Original publication
Serial troponin-I and long-term outcomes in subjects with suspected acute coronary syndrome. Eur J Prev Cardiol. Published 6 December 2023. doi:10.1093/eurjpc/zwad373
Summarised from the published abstract; every number is checked against it