Heart failure & cardiomyopathiesCohort study
Serially Measured Metabolic Plasma Biomarkers and Adverse Outcomes in Chronic Heart Failure: A Longitudinal NMR Spectroscopy Study in Two Cohorts
- Longitudinal NMR Spectroscopy Study in Two Cohorts
- serial blood sampling
- joint models
- adjusted for relevant clinical covariates
Authors' conclusion
Serially measured nuclear magnetic resonance-derived lipoprotein and metabolic biomarkers were associated with the primary end point in chronic stable HF. These findings support further evaluation of serial metabolic profiling as a complementary approach to risk assessment in HF.
Study context
- Population
- Patients with chronic stable heart failure (HF) in 2 independent cohorts with serial blood sampling (Bio-SHiFT and TRIUMPH)2 independent HF cohorts · Bio-SHiFT 382 · TRIUMPH 233
- Participants
- 382 vs 233
- Exposure
- associations between current levels of serially measured biomarkers and the cohort-specific primary end point
- Bio-SHiFTn = 382
- TRIUMPHn = 233
- Outcome
- Composite of:
- HF hospitalization
- Advanced HF therapy
- Cardiovascular death (cohort-specific primary end point)
Main finding
As reported in the abstract
Hazard ratio, per Z score of natural log-transformed biomarker (95% CI)
S-high-density lipoprotein particleBio-SHiFT; higher current levels associated with lower risk
0.59(0.45–0.78)
high-density lipoprotein subclass 2 particlelower risk
0.57(0.42–0.80)
total high-density lipoprotein particlelower risk
0.54(0.41–0.70)
mean high-density lipoprotein particle sizegreater size associated with higher risk
1.52(1.23–1.87)
inflammation vulnerability indexhigher risk
3.11(2.07–4.88)
metabolic malnutrition indexhigher risk
1.98(1.38–2.96)
metabolic vulnerability indexhigher risk
3.79(2.43–5.98)
Per Z score of natural log-transformed biomarker, as printed
Observational data: associations, not effects.
Original publication
Serially Measured Metabolic Plasma Biomarkers and Adverse Outcomes in Chronic Heart Failure: A Longitudinal NMR Spectroscopy Study in Two Cohorts. Circ Heart Fail. Published 6 August 2026. doi:10.1161/circheartfailure.125.013971
Summarised from the published abstract; every number is checked against it