Coronary disease & ACSCohort study
Severe infections as risk factors for acute myocardial infarction: a nationwide, Danish cohort study from 1987 to 2018
- Nationwide matched cohort study
- sex- and age-matched (2 unexposed controls)
- time-dependent Cox proportional hazards model
Authors' conclusion
Acute infections are associated with increased relative rates of AMI across different infection sites and age groups with higher relative rates found for pneumonia.
Study context
- Population
- Adults hospitalized with infection, Danish nationwide registers, 1987–2018
- Participants
- 702,596 infected adults
- Exposure
- Hospitalization with severe infection vs matched unexposed controls
- Pneumonian = 344,319
- Urinary tract infection (UTI)n = 270,101
- Soft tissue/bone infectionn = 66,718
- Central nervous system (CNS) infectionn = 17,025
- Endocarditisn = 4,433
- Outcome
- First-time MI
- Follow-up
- Within 10 years
Main finding
As reported in the abstract
0-30 days post-exposure
Each group vs unexposed controlsHazard ratio (95% CI)
Pneumoniaadjusted
3.39(3.15–3.65)
UTIadjusted
2.44(2.21–2.70)
Soft tissue/bone infectionadjusted
1.84(1.45–2.33)
Endocarditisonly at 31-90 days
2.28(1.20–4.33)
Observational data: associations, not effects.
Original publication
Severe infections as risk factors for acute myocardial infarction: a nationwide, Danish cohort study from 1987 to 2018. Eur J Prev Cardiol. Published 22 October 2024. doi:10.1093/eurjpc/zwae344
Summarised from the published abstract; every number is checked against it