Coronary disease & ACSCohort study
Severe obesity in patients with ST-elevation myocardial infarctions: association with age, temporal trends, and clinical outcomes
- Retrospective cohort study
- single-centre
- consecutive patients
Authors' conclusion
The significant increase in the prevalence of severe obesity among patients with STEMI, particularly among females and younger individuals
Study context
- Population
- Consecutive ST-elevation myocardial infarction (STEMI) patients admitted to a German heart centre, 2006–2022, in 5 WHO body mass index (BMI) groups
- Participants
- 11,629 patients
- Exposure
- Severe obesity vs normal weight
- Severe obesityn = 269
- Outcome
- Prevalence of severe obesity (BMI ≥ 40 kg/m²) in STEMI; association with age, temporal trends and outcomes
Main finding
As reported in the abstract
Prevalence of severe obesity
Severe obesity
2.3%
269 of 269
Observational data: associations, not effects.
Further findings
Age · younger on average
difference 8.6 · P < 0.01
| Outcome | Severe obesity | Normal weight | adjusted HR (95% CI) | P value | |
|---|---|---|---|---|---|
| 30-day mortality | 14.2% | 9.2% | 1.99 (1.4–3.0) | P < 0.01 | |
| 5-year mortality | 30.6% | 20.6% | 2.03 (1.4–2.9) | P < 0.01 | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Age
- Severe obesity more likely female and diabetic
Prevalence trend of severe obesity, 2006-13 vs 2013-22
- Overall
- 1.9 to 2.6%, P = 0.014
- Females
- 2.5-3.7%, P = 0.052
- Females <55 years (+128%)
- 4.9-11.3%, P < 0.01
- Men <55 years (+71%)
- 2.2-3.7%, P < 0.01
Treatment outcomes and in-hospital adverse events
- Not affected by severe obesity
Original publication
Severe obesity in patients with ST-elevation myocardial infarctions: association with age, temporal trends, and clinical outcomes. Eur J Prev Cardiol. Published 31 July 2025. doi:10.1093/eurjpc/zwaf411
Summarised from the published abstract; every number is checked against it