Arrhythmias & electrophysiology
Severity of Brugada syndrome disease manifestation and risk of new-onset depression or anxiety: a Danish nationwide study
Main finding · New-onset depression or anxietyResult — go to the resultHazard ratio 3.43 CI 1.46–8.05Authors' conclusion
Approximately, one-sixth of patients with BrS developed new-onset depression or anxiety following a diagnosis of BrS. Symptomatic BrS disease manifestation was significantly associated with new-onset depression or anxiety.
Study context
- Population
- Danish patients diagnosed with Brugada syndrome 2006–2018, no history of psychiatric disease, ≥6 months follow-up45.3% symptomatic
- Participants
- 223 patients
- Exposure
- Symptomatic vs asymptomatic/unspecified Brugada syndrome (BrS) at diagnosis
- Symptomaticn = 101
- Asymptomatic/unspecifiedn = 122reference
- Outcome
- New-onset depression or anxiety (prescriptions and diagnosis codes)
- Follow-up
- Up to 5 years after diagnosis
Methodological detailsnationwide registries
- Nationwide registries
Main finding
New-onset depression or anxiety · median follow-up 5.0 years
Hazard ratio
3.43
CI 1.46–8.05
Events by group
Symptomaticvs Asymptomatic/unspecified
HR 3.43 (CI 1.46–8.05)
As reported in the abstract
- Overall new-onset depression or anxiety
- 15.7% (35/223)
Observational data: associations, not effects.
Further findings
New-onset depression or anxiety by age (lower vs. upper tertile)
- Older age (lower vs. upper tertile) HR
- 4.41, 1.42-13.63
All-cause mortality
- Deaths
- 4, 1.8%
- Developed depression or anxiety before death
- 3/4
Original publication
Severity of Brugada syndrome disease manifestation and risk of new-onset depression or anxiety: a Danish nationwide study. Europace. Published 2 May 2023. doi:10.
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