Heart failure & cardiomyopathies
Sex-Associated Differences in the Clinical Outcomes of Left Ventricular Assist Device Recipients: Insights From Interagency Registry for Mechanically Assisted Circulatory Support
Authors' conclusion
Among left ventricular assist device recipients, the risk of death, the cumulative incidence of heart transplantation, and adverse events differ by sex across the social and clinical subgroups.
Study context
- Population
- LV assist device recipients enrolled in INTERMACS, 2005–2017
- Participants
- 18,525 recipients
- Exposure
- Females vs males
- Femalesn = 3,968
- Outcome
- All-cause mortality
Methodological detailsregistry (INTERMACS), multivariable-adjusted Cox model, prespecified interaction testing
- Registry (INTERMACS)
- Multivariable-adjusted Cox model
- Prespecified interaction testing
Main finding
As reported in the abstract
All-cause mortality by sex, across subgroups
Females vs MalesAdjusted hazard ratio (CI)
Hispanic
1.75(1.23–2.47)
non-Hispanic White
1.15(1.07–1.25)
Bridge to candidacy
1.32(1.18–1.48)
- Risk of death did not vary by sex in center volume subgroup
- P for interaction = 0.44
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HRadj (CI) | |
|---|---|---|
| Heart transplantation by sex, across race/ethnicity subgroupsFemalesvs MalesHispanic | 0.60 (0.40–0.89) | |
| Heart transplantation by sex, across race/ethnicity subgroupsFemalesvs Malesnon-Hispanic Black | 0.76 (0.67–0.86) | |
| Heart transplantation by sex, across race/ethnicity subgroupsFemalesvs Malesnon-Hispanic White | 0.88 (0.80–0.96) | |
| 0.512Adjusted hazard ratio (log scale) |
- Heart transplantation by sex, across race/ethnicity subgroups — Heart transplantation did not vary by sex in center volume subgroup
- Pinteraction=0.40
- Heart transplantation by sex, across race/ethnicity subgroups: race/ethnicity interaction Pinteraction<0.001
Safety
Postimplantation adverse events
- Higher incidence rate of adverse events in females vs males, overall and across all subgroups
Original publication
Sex-Associated Differences in the Clinical Outcomes of Left Ventricular Assist Device Recipients: Insights From Interagency Registry for Mechanically Assisted Circulatory Support. Circ Heart Fail. Published 26 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →