Sex-based differences in adverse left ventricular remodelling and clinical outcomes after ST-segment elevation myocardial infarction
Main finding · Adverse LVR (>15% of LV end-diastolic volume and a decrease of >3% in LV ejection fraction)Result — go to the resultOdds ratio 0.80 95% CI 0.39–1.64Authors' conclusion
The higher rate of MACE after STEMI in women compared to men appears to be associated with a higher prevalence of CVRF and comorbidities rather than a more significant occurrence of adverse LVR.
Study context
- Population
- Patients with a first ST-elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI)17.5% women, mean age: 58.71 ± 11.85 years
- Participants
- 1,067 patients
- Comparison
- Female vs male sex
- Outcome
- Adverse LVR (>15% of LV end-diastolic volume and a decrease of >3% in LV ejection fraction)
- Follow-up
- 6 months
Main finding
As reported in the abstract
Odds ratio
0.80
95% CI 0.39–1.64
P = 0.536
Womenvs Men
OR 0.80 (95% CI 0.39–1.64); P = 0.536
Secondary outcomes
| Outcome | Women | Men | Hazard ratio (95% CI) | P value | |
|---|---|---|---|---|---|
| MACE (cardiovascular death, heart failure admission, or ventricular arrhythmias) (secondary endpoint) · Follow-up 6.94 years (IQR: 4.48-9.32 years)After adjusting for baseline differences and CVRF | 22.6% | 15.4% | 1.21 (0.81–1.81) | P = 0.343 | |
| 0.512Hazard ratio (log scale) |
- MACE (cardiovascular death, heart failure admission, or ventricular arrhythmias) (secondary endpoint) — MACE overall
- 177 patients (16.7%)
- MACE (cardiovascular death, heart failure admission, or ventricular arrhythmias) (secondary endpoint): unadjusted women vs men P = 0.017
Original publication
Sex-based differences in adverse left ventricular remodelling and clinical outcomes after ST-segment elevation myocardial infarction. Eur Heart J Cardiovasc Imaging. Published 10 February 2025. doi:10.
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