Valvular & structural heart diseaseResearch article
Sex-Based Differences in Outcomes After Transcatheter Edge-to-Edge Repair for Severe Mitral Regurgitation
- Study of patients undergoing mitral transcatheter edge-to-edge repair (M-TEER)
Authors' conclusion
Women undergoing M-TEER presented at a more advanced age and with higher symptom burden than men, potentially reflecting sex-specific clinical trajectories and differing MR etiologies. However, midterm outcomes, including all-cause mortality and HF rehospitalization, were comparable between sexes.
Study context
- Population
- Patients undergoing mitral transcatheter edge-to-edge repair (M-TEER) for severe mitral regurgitation (MR), May 2014 to October 2025patients enrolled, 119 (40.6%) were women
- Participants
- 293 patients
- Comparison
- Men vs women after M-TEER
- Femalesn = 119
- Outcome
- All-cause mortality
- Follow-up
- 6 months
Main finding
As reported in the abstract
Adjusted odds ratio
0.929
95% CI 0.474–1.822
P = 0.830
By group
Secondary outcomes
Prevalence of coronary artery disease (baseline) · higher in males
P = 0.002
Proportion of functional MR (baseline) · higher in males
HF-related rehospitalization (secondary endpoint) · 6 months · comparable rates
P = 0.576
| Outcome | adjusted OR (95% CI) | P value | |
|---|---|---|---|
| HF-related rehospitalization (secondary endpoint) · 6 months · comparator group of the OR not stated in the abstract · comparable rates | 1.151 (0.520–2.548) | P = 0.729 | |
| 0.20.5125Adjusted odds ratio (log scale) |
| Outcome | Estimate | P value |
|---|---|---|
| Functional capacity (6-minute walk test) at baseline · significantly lower functional capacity in women | P = 0.001 | |
| Mean improvement of functional capacity (secondary endpoint) · 6 months · similar between male and female patients | P = 0.778 |
Severity of MR (baseline)
- Compared with men, women had a similar severity of MR independent of its etiology
Original publication
Summarised from the published abstract; every number is checked against it