Prevention & lipidsResearch article
Sex chromosomes and cardiovascular disease
- Narrative review
Authors' conclusion
Overall, this review underscores the complexity of sex chromosome-related mechanisms in CVD
Main finding
As reported in the abstract
Role of sex chromosomes in CVD (loss of chromosomes, genetic variation, altered expression)
- Mosaic loss of the Y chromosome (mLoY) is the most well-characterized mechanism linking sex chromosomes to cardiovascular disease (CVD), with substantial evidence in HF
- mLoY involved in myocardial fibrosis and cardiac macrophage infiltration, both mediated by TGF-β signalling
- X chromosome inactivation escape (higher expression of specific X-linked genes in females) may explain sex differences in CVD; human outcome impact unclear
- narrative review
Original publication
Sex chromosomes and cardiovascular disease. Eur J Prev Cardiol. Published 15 April 2025. doi:10.1093/eurjpc/zwaf224
Summarised from the published abstract; every number is checked against it