Cohort study
Sex differences among subcutaneous implantable cardioverter-defibrillator recipients: a propensity-matched, multicentre, international analysis from the i-SUSI project
- Registry-based cohort study
- propensity-score matched (1:1)
- multicentre
- international
Authors' conclusion
In a propensity-matched cohort of S-ICD recipients, women are less likely to experience appropriate ICD therapy, while not showing higher risk of device-related complications.
Study context
- Population
- Consecutive unselected subcutaneous ICDs (S-ICD) recipients in the i-SUSI registry399 (23.5%) females
- Participants
- 1,698 participants
- Exposure
- Women vs men among S-ICD recipients
- Femalen = 374reference
- Malen = 374
- Outcome
- Rate of appropriate shocks
- Follow-up
- Median 26.5 [12.7-42.5] months
Main finding
Appropriate shocks
Adjusted hazard ratio
1.648
CI 0.999–2.655
P = 0.048
By group
Male vs Female
aHR 1.648 (CI 0.999–2.655); P = 0.048
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Low risk of conversion failure per PRAETORIAN score
- Women at lower risk of conversion failure (73.4% vs. 81.3%)
- P = 0.049
Safety
Device-related complications (rate/year)
- No significant difference: 6.3% vs. 5.8%
- log-rank P = 0.595
- Sex not a predictor after controlling for confounders
Inappropriate shocks (rate/year)
- No significant difference: 4.3% vs. 3.1%
- log-rank P = 0.375
- Sex not a predictor after controlling for confounders
Original publication
Sex differences among subcutaneous implantable cardioverter-defibrillator recipients: a propensity-matched, multicentre, international analysis from the i-SUSI project. Europace. Published 2 May 2024. doi:10.1093/europace/euae115
Summarised from the published abstract; every number is checked against it