Heart failure & cardiomyopathies
Sex Differences in Clinical Characteristics and Long-Term Clinical Outcomes in Asian Hospitalized Heart Failure Patients
Authors' conclusion
With more coronary risk factors and medical comorbidities, less cardiac remodelling and better adherence to guideline-directed HF therapy, women hospitalized for acute decompensated HF demonstrated superiority over men in long-term post-discharge clinical outcomes, including all-cause mortality, cardiovascular mortality and 1 year mortality, and mainly in HF with preserved and mid-range EF categories, in the Asian HF cohort.
Study context
- Population
- Asian patients hospitalized for acute decompensated heart failure (HF), 2011–2020
- Participants
- 12,428 patients
- Exposure
- Women vs men
- Womenn = 5,910
- Menn = 6,518reference
- Outcome
- Post-discharge long-term clinical outcomes: all-cause mortality, CV mortality, 1 year mortality, HF rehospitalization
- Follow-up
- Over 8 years
Methodological detailsuniversity HF cohort
- University HF cohort
Main finding
As reported in the abstract
Women vs MenAdjusted hazard ratio (95% CI)
All-cause mortality
0.89(0.84–0.93)
CV mortality
0.89(0.80–0.99)
1 year mortality
0.91(0.84–0.99)
HF rehospitalization
1.02(0.95–1.09)
Observational data: associations, not effects.
Further findings
Age
P < 0.0001
All-cause mortality, by ejection fraction (EF) category (subgroup)
- Lower mortality in women in HFpEF (>50%) and HF with mildly reduced EF (40%-50%), but not in HFrEF (<40%)
Subgroup interaction factors
- BMI, coexisting hypertension and COPD were significant interacting factors
Original publication
Sex Differences in Clinical Characteristics and Long-Term Clinical Outcomes in Asian Hospitalized Heart Failure Patients. ESC Heart Fail. Published 11 June 2024. doi:10.
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