Heart failure & cardiomyopathiesMeta-analysis
Sex Differences in Dilated Cardiomyopathy
- Review with systematic review and meta-analysis
Authors' conclusion
These findings highlight the influence of sex and genotype on clinical outcomes.
Study context
- Population
- Patients with dilated cardiomyopathy
- Comparison
- Male vs female dilated cardiomyopathy (DCM) patients, by genotype
Pooled result
As reported in the abstract
Arrhythmic events and HF by sex and genotype
- Men: PLN, DSP and LMNA variant carriers had higher arrhythmic event rates than TTNtv and BAG3 carriers
- Women: RBM20, DSP and PLN variants had the highest arrhythmic risk, TTNtv carriers the lowest
- PLN and LMNA variants had the highest HF risk in both sexes
- BAG3, RBM20 and TTN variants had lower HF rates in female than male carriers
Original publication
Sex Differences in Dilated Cardiomyopathy. J Am Coll Cardiol. Published 26 November 2025. doi:10.1016/j.jacc.2025.09.1603
Summarised from the published abstract; every number is checked against it