Coronary disease & ACSSecondary analysis
Sex Differences in Fractional Flow Reserve– or Intravascular Ultrasound–Guided Percutaneous Coronary Intervention
- Secondary analysis of the FLAVOUR randomised trial
Authors' conclusion
In cases of intermediate stenosis, despite receiving fewer interventions, women had more favorable outcomes than men. The use of FFR led to a lower PCI rate but had a similar prognostic value compared with IVUS in both women and men.
Study context
- Population
- Patients with intermediate coronary stenosis in the FLAVOUR trial (fractional flow reserve (FFR)- vs IVUS-guided percutaneous coronary intervention (PCI))30% women
- Participants
- 1,619 patients
- Comparison
- Women vs men, by FFR- or IVUS-guided PCI strategy
- Primary endpoint
- TVF (cardiac death, target vessel MI, target vessel revascularization)
- Follow-up
- 24 months
Primary result
As reported in the abstract
TVF
Further findings
TVF in patients with deferral of PCI (subgroup)
PCI rate, women vs men
- Lower PCI rate in women than men (40.8% vs 47.9%), mainly with FFR guidance
- P = 0.008
Target vessel failure (TVF) in patients who underwent PCI (subgroup)
- Lower TVF in women vs men not observed among patients who underwent PCI
Clinical outcomes, FFR- vs IVUS-guided, by sex
- No differences between FFR- and IVUS-guided strategies in women or men
Original publication
Sex Differences in Fractional Flow Reserve– or Intravascular Ultrasound–Guided Percutaneous Coronary Intervention. JACC Cardiovasc Interv. Published 27 August 2023. doi:10.1016/j.jcin.2023.08.017
Summarised from the published abstract; every number is checked against it