Sex Differences in Hospitalizations in the 6 Months Before a Diagnosis of Transthyretin Amyloid Cardiomyopathy

doi:10.1016/j.jacadv.2026.102627

Heart failure & cardiomyopathiesCohort study

Sex Differences in Hospitalizations in the 6 Months Before a Diagnosis of Transthyretin Amyloid Cardiomyopathy

JACC AdvPublication date not resolved

retrospective cohort study

Authors' conclusion

Hospitalization occurs in nearly half of all patients in the 6 months before their admission with a diagnosis of ATTR-CM. The most common reasons for prior hospitalization include hypertensive heart and chronic kidney disease, sepsis, atrial arrhythmia, and heart failure. Previous hospitalization is more common among females and in the overall population is associated with a 2-fold increase in mortality.

Study context

Population: Patients hospitalized with transthyretin amyloid cardiomyopathy (ATTR-CM) in the National Readmissions Database, 2018–2020patients hospitalized with ATTR-CM, 4,545 (41.1%) of them had 1 or more hospital admission within the preceding 6 months
Participants: 10,975 patients

Exposure: Hospitalizations in the 6 months preceding an index admission with ATTR-CM, stratified according to sex

Main finding

As reported in the abstract

1 or more hospital admission within the preceding 6 months · 6 months before index admission

of the 10,975 patients hospitalized with ATTR-CM, patients with 1 or more hospital admission within the preceding 6 months

4,545 (41.1%)

Observational data: associations, not effects.

Further findings

Factors associated with previous admission · 6 months before index admission

Comparison	Lower odds ←→ Higher odds	OR (95% CI)	P value
female sex · increased risk of previous admission		1.39 (1.14–1.69)	P = 0.001
hypertension · increased risk of previous admission		1.40 (1.04–1.88)	P = 0.026
	0.512Odds ratio (log scale)

Mortality during the index admission with ATTR-CM

Comparison	Lower odds ←→ Higher odds	OR (95% CI)	P value
previous 6-month hospitalization · 2-fold increased risk of mortality		2.06 (1.32–3.20)	P = 0.001
	0.20.5125Odds ratio (log scale)

Financial income

Females hospitalized with ATTR-CM were more likely to have a lower financial income based on zip code quartiles

Most common primary diagnoses for the preceding 6-month admissions · 6 months before index admission

hypertensive heart disease with or without renal disease: 32.5%
sepsis: 4.9%
atrial fibrillation/flutter: 4.1%
heart failure: 3.6%

Original publication

Sex Differences in Hospitalizations in the 6 Months Before a Diagnosis of Transthyretin Amyloid Cardiomyopathy. JACC Adv. doi:10.1016/j.jacadv.2026.102627

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Summarised from the published abstract; every number is checked against it