Valvular & structural heart disease
Sex differences in left atrial volumes, mechanics, and stiffness in primary mitral regurgitation—a combined 2D and 3D echocardiographic study
Main findingResult — go to the resultAdjusted risk of increased LA stiffness (logistic regression) four-fold 95% CI 1.2–13.1Authors' conclusion
Women with significant primary MR have more impaired LA reservoir mechanics and increased LA stiffness compared with men despite lower MR regurgitant volumes and similar indexed LA size.
Study context
- Population
- Patients with significant (moderate or greater) primary mitral regurgitation
- Participants
- 111 patients
- Exposure
- Women vs men
- Outcome
- LA size (3D LA volumes), mechanics (reservoir and contractile strain) and stiffness ((E/e')/LASr) by sex
Methodological detailscombined 2D and 3D echocardiography
- Combined 2D and 3D echocardiography
Main finding
As reported in the abstract
Adjusted risk of increased left atrial (LA) stiffness (logistic regression)
four-fold
95% CI 1.2–13.1
P = 0.02
By group
Women
- LA reservoir strain
- 22.2%
- LA stiffness
- 0.56
Men
- LA reservoir strain
- 25.0%
- LA stiffness
- 0.44
LA reservoir strain
Women22.2%
Men25.0%
LA stiffness
Women0.56
Men0.44
- LA reservoir strain lower and LA stiffness higher in women
- P < 0.05
- Female sex associated with higher LA stiffness independent of age, minimum LAV, LV global longitudinal strain, DM and CAD (linear regression, R2 = 0.56)
- all P < 0.05
Observational data: associations, not effects.
Further findings
Baseline characteristics
- Women older, higher heart rate, lower BMI and lower mitral regurgitation (MR) regurgitant volumes
- P < 0.05
Original publication
Sex differences in left atrial volumes, mechanics, and stiffness in primary mitral regurgitation—a combined 2D and 3D echocardiographic study. Eur Heart J Cardiovasc Imaging. Published 12 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →