Heart failure & cardiomyopathies
Sex Differences in Left Bundle Branch Area Pacing Versus Biventricular Pacing for Cardiac Resynchronization Therapy
Authors' conclusion
Men and women undergoing LBBAP for CRT had similar clinical outcomes. Men undergoing LBBAP showed a lower risk of heart failure-related hospitalizations and all-cause mortality compared to men undergoing BIVP, whereas there was no difference between LBBAP and BIVP in women.
Study context
- Population
- Patients with LVEF ≤35% and left bundle branch block, or LVEF ≤40% with expected RV pacing >40%, undergoing initial cardiac resynchronization therapy (CRT)
- Exposure
- Left bundle branch area pacing (LBBAP) vs biventricular pacing (BIVP) as initial CRT, by sex
- Outcome
- HF-related hospitalization and all-cause mortality (composite)
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
HF hospitalization and all-cause mortality, by sex (subgroup analysis)
LBBAP (men) vs BIVP (men): P = 0.004 · LBBAP (women) vs BIVP (women): P = 0.23 · LBBAP (men) vs LBBAP (women): P = 0.46 · BIVP (women) vs BIVP (men): P = 0.03
Observational data: associations, not effects.
Safety
Procedure-related complications
- Complication rates consistent across all groups
Original publication
Sex Differences in Left Bundle Branch Area Pacing Versus Biventricular Pacing for Cardiac Resynchronization Therapy. JACC Clin Electrophysiol. Published 16 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →