Coronary disease & ACSCohort study
Sex differences in medication adherence and medication-associated mortality after coronary artery bypass grafting
- Cohort study
- nationwide drug purchase registers
- multivariable-adjusted Cox regression with sex interaction term
Authors' conclusion
No major sex differences in medication adherence were observed during 10 years of follow-up. Use of beta-blockers was associated with lower risk of mortality in women compared with men.
Study context
- Population
- Patients who underwent coronary artery bypass grafting (CABG) between 1998 and 202118% women
- Participants
- 9,857 patients
- Exposure
- Women vs Men
- Outcome
- Association between adherence (statins, beta-blockers, RAAS inhibitors) and all-cause mortality, by sex
Main finding
As reported in the abstract
All-cause mortality with medication use, by sex
Each group vs menHazard ratio (95% CI)
Statin usewomen
0.49(0.41–0.59)
Statin usemen
0.54(0.50–0.59)
Beta-blocker adherencewomen
0.66(0.55–0.78)
Beta-blocker adherencemen
0.82(0.75–0.90)
Observational data: associations, not effects.
Further findings
Medication use immediately after CABG (similar in men and women)
- Statins
- 90%
- Renin-angiotensin-aldosterone system (RAAS) inhibitors
- 62%
- Beta-blockers
- 93%
- Sex difference
- P ≥ 0.57 for all
Adherence at 10 years (non-significant trend towards greater adherence in women)
- Statins
- 84%
- Beta-blockers
- 85%
- RAAS inhibitors
- 66%
Original publication
Sex differences in medication adherence and medication-associated mortality after coronary artery bypass grafting. Eur J Prev Cardiol. Published 12 June 2025. doi:10.1093/eurjpc/zwaf339
Summarised from the published abstract; every number is checked against it