Coronary disease & ACSCohort study
Sex differences in myocardial infarction care and outcomes: a longitudinal Scottish National Data-Linkage Study
- Longitudinal cohort study
- national data-linkage
- 2:1 age, sex and general practice-matched general population controls
Authors' conclusion
Women were undertreated compared to men after MI. Their survival and outcome benefits may be improved further.
Study context
- Population
- All myocardial infarction (MI) admissions aged 45–80 years across Scotland, 2010–2016, followed up until end of 2021
- Participants
- 47,063 MI patients
- Exposure
- Women vs men with MI
- Womenn = 15,776
Main finding
As reported in the abstract
In-hospital care and outcomes
Women vs MenRisk ratio (95% CI)
PCI
0.87(0.86–0.89)
secondary prevention at discharge
0.94(0.93–0.95)
in-hospital mortality, after adjustment; no difference
1.06(0.99–1.13)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Long-term outcomes after full adjustment · median follow-up 8.2 (6.7, 10.1) years — Women vs Men · all-cause mortality | 0.92 (0.89–0.95) | |
| Long-term outcomes after full adjustment · median follow-up 8.2 (6.7, 10.1) years — Women vs Men · CV mortality | 0.82 (0.78–0.87) | |
| Long-term outcomes after full adjustment · median follow-up 8.2 (6.7, 10.1) years — Women vs Men · CV events | 0.92 (0.88–0.95) | |
| 0.512Hazard ratio (log scale) |
Long-term outcomes after full adjustment · median follow-up 8.2 (6.7, 10.1) years
- Women had higher crude rates of adverse outcomes
- Female survival advantage seen in general population controls attenuated in MI patients
Original publication
Sex differences in myocardial infarction care and outcomes: a longitudinal Scottish National Data-Linkage Study. Eur J Prev Cardiol. Published 27 November 2024. doi:10.1093/eurjpc/zwae333
Summarised from the published abstract; every number is checked against it