Coronary disease & ACSCohort study
Sex Differences in Outcomes of Complex Percutaneous Coronary Interventions Assisted With Mechanical Circulatory Support Devices
- retrospective analysis
- single center
Authors' conclusion
Women undergoing complex PCI with MCS support experienced higher procedural risk and worse early outcomes, yet adjusted 1-year MACE rates were comparable to men. The marked absolute differences in bleeding and mortality highlight the need for sex-specific approaches to patient selection, procedural planning, and post-PCI management in this high-risk population.
Study context
- Population
- Hemodynamically stable patients who underwent complex percutaneous coronary intervention (PCI) assisted with either an intra-aortic balloon pump or Impella (Abiomed), 2017 to 2022included patients, 24% were women (n = 145)
- Participants
- 605 patients
- Exposure
- Women vs men undergoing mechanical circulatory support (MCS)-assisted complex PCI
- Womenn = 145
- Outcome
- Major adverse cardiovascular events (MACE):
- Composite of all-cause death
- Myocardial infarction
- Stroke
- Follow-up
- 1 year
Main finding
As reported in the abstract
Adjusted hazard ratio
1.34
95% CI 0.74–3.03
P = 0.337
By group
Women vs Men
adjusted HR 1.34 (95% CI 0.74–3.03); P = 0.337
Observational data: associations, not effects.
Secondary outcomes
Mortality · 1 year
- Mortality: P = 0.003
Baseline characteristics
- Women had a higher comorbidity burden, presented more frequently with non-ST-segment elevation myocardial infarction
Original publication
Sex Differences in Outcomes of Complex Percutaneous Coronary Interventions Assisted With Mechanical Circulatory Support Devices. JACC Adv. Published 23 February 2026. doi:10.1016/j.jacadv.2026.102622
Summarised from the published abstract; every number is checked against it