Acute cardiac care & resuscitation
Sex differences in symptoms of anxiety, depression, post-traumatic stress disorder, and cognitive function among survivors of out-of-hospital cardiac arrest
Authors' conclusion
Symptoms of anxiety and PTSD are frequent in OHCA survivors, and female survivors report significantly more symptoms of anxiety and PTSD compared with males. In particular, young females were significantly more symptomatic than young males.
Study context
- Population
- Comatose out-of-hospital cardiac arrest (OHCA) survivors attending a structured 3-month follow-up, 2016–2021381 invited
- Participants
- 288 survivors
- Exposure
- Females vs males
- Femalesn = 53
- Malesn = 235reference
- Outcome
- Symptoms of anxiety/depression (HADS ≥8), PTSD (PCL-5 ≥33) and cognitive function (MoCA)
- Follow-up
- 3 months
Main finding
As reported in the abstract
3-month follow-up
Values · 3-month follow-up
PTSD
- Anxiety: Females vs Males
- P = 0.01
- Post-traumatic stress disorder (PTSD): Females vs Males
- P = 0.01
- Female sex associated with anxiety, multivariable logistic regression adjusted for pre-specified covariates: OR
- 2.18 (CI 1.09-4.38, P = 0.03)
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| Anxiety, young (below median age) femalesvs young males (subgroup)Adjusted | 3.31 (1.32–8.29) | P = 0.01 | |
| 0.10.31310Odds ratio (log scale) |
Original publication
Sex differences in symptoms of anxiety, depression, post-traumatic stress disorder, and cognitive function among survivors of out-of-hospital cardiac arrest. Eur Heart J Acute Cardiovasc Care. Published 8 August 2023. doi:10.
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