Heart failure & cardiomyopathiesCohort study
Sex Differences in the Clinical Presentation and Natural History of Dilated Cardiomyopathy
- Prospective cohort study
- observational
Authors' conclusion
Female DCM patients have a paradoxical early increase in major HF events despite less prevalent myocardial fibrosis and a milder phenotype at presentation.
Study context
- Population
- Patients with dilated cardiomyopathy (DCM)median follow-up 3.9 years
- Participants
- 206 vs 398
- Exposure
- Females vs males with DCM
- Femalesn = 206
- Malesn = 398reference
Main finding
CV mortality or major HF events · 2 years
Adjusted hazard ratio
3.14
95% CI 1.55–6.35
P = 0.001
By group
Females vs Males
adjusted HR 3.14 (95% CI 1.55–6.35); P = 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mid-wall myocardial fibrosis at baseline
- Mid-wall myocardial fibrosis at baseline — Females had higher LVEF, smaller LV volumes and lower hs-cTnI than males
- all P < 0.05
- Mid-wall myocardial fibrosis at baseline: all P < 0.05
Primary outcome between 2 and 5 years
- Effect of sex as a prognostic modifier attenuated
Mid-wall myocardial fibrosis at baseline
- No difference in time from diagnosis, age at enrollment, NT-proBNP, pathogenic DCM genetic variants, fibrosis extent or heart failure (HF) medications
Sex-specific prognostic factors
- Age, mid-wall fibrosis, LVEF, LA volume, NT-proBNP, hs-cTnI, LBBB and NYHA class were not sex-specific prognostic factors
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Sex Differences in the Clinical Presentation and Natural History of Dilated Cardiomyopathy. JACC Heart Fail. Published 29 November 2023. doi:10.1016/j.jchf.2023.10.009
Summarised from the published abstract; every number is checked against it