Sex differences in the intensity of statin prescriptions at initiation in a primary care setting
Authors' conclusion
Compared with men, women were less likely to be prescribed high-intensity statins at initiation and to achieve treatment targets, both in people without and with a history of CVD, and independent of differences in other individual and clinical characteristics.
Study context
- Population
- Statin users aged 40–99 years without and with cardiovascular diseases (CVD), primary care46% women
- Participants
- 82,714 users
- Exposure
- Women vs men
- Outcome
- High-intensity statin prescription at initiation
- Follow-up
- At initiation
Methodological detailsprimary care, electronic health records (PHARMO Data Network)
- Primary care
- Electronic health records (PHARMO Data Network)
Main finding
As reported in the abstract
Women vs MenRelative risk (95% CI)
Without history of CVD
0.69(0.63–0.75)
With CVD
0.77(0.74–0.81)
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | |
|---|---|---|
| Achievement of LDL-C target after statin initiationWomenvs MenWithout CVD | 0.98 (0.97–1.00) | |
| Achievement of LDL-C target after statin initiationWomenvs MenWith history of CVD | 0.94 (0.89–0.98) | |
| 0.512Relative risk (log scale) |
High-intensity statin at initiation over time · 2011–2020
- Proportion increased between 2011 and 2020 in both sexes
Original publication
Sex differences in the intensity of statin prescriptions at initiation in a primary care setting. Heart. Published 5 April 2024. doi:10.
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