Sex Differences in the Safety and Efficacy of Different Durations of DAPT After Percutaneous Coronary Intervention (PCI)
Authors' conclusion
No significant sex-based differences in NACE or MACE were observed with different durations of DAPT after PCI, while a lower bleeding risk was observed with shorter DAPT (1-3 months) among both sexes. This suggests that shorter DAPT may be preferred in both sexes following PCI, especially in those with high bleeding risk.
Study context
- Population
- Men and women in randomized controlled trials that compared any 2 of 1, 3, 6, or 12 months of DAPT after PCIFifteen randomized controlled trials (RCTs) · men 44,610 · women 15,132
- Comparison
- Any 2 of 1, 3, 6, or 12 months of DAPT after PCI, in men and women
- Outcome
- NACE or MACE
Pooled result
As reported in the abstract
- No difference in net adverse clinical events (NACE) or major adverse cardiovascular events (MACE) between 1, 3, 6, or 12 months of DAPT in both sexes
Further pooled results
Bleeding
- In both men and women, 1 and 3 months of DAPT were each associated with lower risk of bleeding compared with 12 months of DAPT
- In women, 3 months of DAPT was associated with a lower risk of bleeding compared with 6 months
Sensitivity analysis of acute coronary syndrome-only trials
- Similar results
Original publication
Sex Differences in the Safety and Efficacy of Different Durations of DAPT After PCI. JACC Adv. Published 8 January 2025. doi:10.
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