Coronary disease & ACSCohort study
Sex differences in trajectories of LDL cholesterol control in chronic coronary syndromes
- Registry-based cohort study (analysis of the CLARIFY registry)
- international
- 5-year follow-up
Authors' conclusion
Women with CCS were less likely to have LDL-C measurement available at baseline, to receive lipid-lowering drugs and consistently exhibited poorer LDL-C control than men over the 5-year follow-up.
Study context
- Population
- Patients with chronic coronary syndromes (CCS) in the international CLARIFY registry with low-density lipoprotein cholesterol (LDL-C) measured at baseline21.6% women
- Participants
- 21,925 patients
- Exposure
- Women vs men
- Outcome
- Cardiovascular (CV) death or MI
- Follow-up
- 5-year follow-up
Main finding
Failure to reach LDL-C target at inclusion · inclusion
Adjusted odds ratio
1.47
95% CI 1.38–1.58
P < 0.001
By group
Women vs Men
aOR 1.47 (95% CI 1.38–1.58); P < 0.001
As reported in the abstract
- Disparity persisted across the 5-year follow-up
- P < 0.001 for every year
Observational data: associations, not effects.
Further findings
| Outcome | Women | Men | Estimate | P value | |
|---|---|---|---|---|---|
| Never reaching target LDL-C during follow-up | 20.7% | 15.8% | aOR 1.44 (95% CI 1.32–1.56) | P < 0.001 | |
| LDL-C measurement available at baseline (initial cohort of 32,376) · women less likely to have measurement | aOR 1.12 (95% CI 1.06–1.18) | P < 0.001 | |||
| CV death or MI by mean LDL-C during follow-up · 5-year follow-up | aHR 1.06 (95% CI 1.04–1.07) | P < 0.001 | |||
| 0.512Ratio (log scale) |
Statin use at inclusion
P < 0.001
Original publication
Sex differences in trajectories of LDL cholesterol control in chronic coronary syndromes. Eur J Prev Cardiol. Published 18 August 2026. doi:10.1093/eurjpc/zwag419
Summarised from the published abstract; every number is checked against it