Aortic & peripheral vascular diseaseMeta-analysis
Sex differences in type A acute aortic dissection: a systematic review and meta-analysis
- Systematic review and meta-analysis
- random-effects model
Authors' conclusion
A female sex phenotype appears to be evident in type A AAD
Study context
- Population
- Patients with type A acute aortic dissection; analyses in surgically treated patients (studies 2004–2022)
- Participants
- 16,069 patients · 16 studies
- Comparison
- Women vs men
- Womenn = 7,142
- Menn = 8,927reference
- Outcome
- Sex differences in clinical features, management and outcomes
Pooled result
In-hospital surgical mortality · in-hospital
Relative risk
1.02
95% CI 0.53–1.99
P = 0.95
Women vs Men
RR 1.02 (95% CI 0.53–1.99); P = 0.95
As reported in the abstract
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Survival · 5 years · survival higher among men | 0.94 (0.92–0.97) | P < 0.001 | |
| Survival · 10 years · survival higher among men | 0.82 (0.74–0.92) | P = 0.004 | |
| 0.512Relative risk (log scale) |
In-hospital mortality, medically treated patients (descriptive) · descriptive analysis
P = 0.59
Clinical features at presentation
- Women older than men but lower body mass index (BMI), body surface area (BSA) and creatinine plasma levels
- Active smoking, bicuspid aortic valve and previous cardiac surgery less common in women; DM more frequent
- Pericardial effusion/cardiac tamponade more frequent in women
Original publication
Sex differences in type A acute aortic dissection: a systematic review and meta-analysis. Eur J Prev Cardiol. Published 11 January 2023. doi:10.1093/eurjpc/zwad009
Summarised from the published abstract; every number is checked against it