Sex-Related Differences in Left Ventricular Geometry Patterns in Patients With Arterial Hypertension
Main finding · LV geometry at baselineResult — go to the resultOdds ratio 2.36 95% CI 2.12–2.62Authors' conclusion
We found sex-related differences in LV geometry among hypertensives. Females have higher risk of LV remodeling at baseline compared with males, with differences persisting at long-term follow-up.
Study context
- Population
- Hypertensives without prevalent CVD, incident MI or CKD > stage III, with normal LVEF43% females
- Participants
- 6,427 participants
- Exposure
- Females vs males
- Outcome
- LV geometry patterns (normal, LVH, eccentric/concentric LVH, LV remodeling)
- Follow-up
- Baseline and long-term
Main finding
LV geometry at baseline
Odds ratio
2.36
95% CI 2.12–2.62
P < 0.001
By group
Females
- Normal geometric pattern
- 50%
- LV hypertrophy (LVH)
- 47%
- Eccentric LVH
- 40%
Males
- Normal geometric pattern
- 72%
- LVH
- 23%
- Eccentric LVH
- 18%
Normal geometric pattern
Females50%
Males72%
LV hypertrophy (LVH)
Females47%
Males23%
Eccentric LVH
Females40%
Males18%
Femalesvs males
OR 2.36 (95% CI 2.12–2.62); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
LV geometry at long-term follow-up · mean 6.1 years (IQR 2.8-8.6 years)
Normal geometry
Eccentric LVH
Concentric LVH
- Left ventricular (LV) geometry at long-term follow-up: each difference P < 0.001
LV geometry at long-term follow-up · mean 6.1 years (IQR 2.8-8.6 years)
- Prevalence of LV remodeling increased in both sexes
Original publication
Sex-Related Differences in Left Ventricular Geometry Patterns in Patients With Arterial Hypertension. JACC Adv. Published 6 September 2024. doi:10.
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