Valvular & structural heart diseaseResearch article
Sex-related differences in outcome of tricuspid valve surgery in severe isolated secondary tricuspid regurgitation
- Isolated TVR studied as a time-dependent covariate
Authors' conclusion
Isolated TVR for STR was associated with decreased HF hospitalizations in both females and males but improved survival only in females. Future studies are needed to understand differences in the natural history of TR between sexes and stratify outcomes after TR intervention by sex.
Study context
- Population
- Patients with severe secondary tricuspid regurgitation (STR) without significant aortic valve or organic mitral valve disease, congenital heart disease, pacemakers, previous valve intervention, malignancy, or end-stage kidney/liver diseasemedian age 76 years, 62% women, 143 underwent isolated TVR
- Participants
- 2,857 patients
- Comparison
- sex differences in the association of isolated tricuspid valve surgical repair/replacement (TVR) with outcomes of mortality and heart failure (HF) hospitalizations in STR
- Isolated TVRn = 143
Main finding
As reported in the abstract
Mortality, by sex · median of 1.6 (IQR 0.2-5.2) years
Hazard ratio (95% CI)
Isolated TVR (females)females
0.54(0.35–0.83)
Isolated TVR (males)males
1.29(0.90–1.83)
Further findings
HF hospitalization
| Comparison | HR (95% CI) | |
|---|---|---|
| Isolated TVR · without interaction with sex | 0.68 (0.46–0.998) | |
| 0.512Hazard ratio (log scale) |
- HF hospitalization: P-interaction=0.51
Deaths and HF hospitalizations during follow-up · median of 1.6 (IQR 0.2-5.2) years
- patients died
- 1771
- had HF hospitalization
- 1259
Original publication
Sex-related differences in outcome of tricuspid valve surgery in severe isolated secondary tricuspid regurgitation. Eur Heart J Cardiovasc Imaging. Published 19 August 2026. doi:10.1093/ehjci/jeag223
Summarised from the published abstract; every number is checked against it