Valvular & structural heart diseaseCross-sectional study
Sex-related differences in severe native valvular heart disease: the ESC-EORP Valvular Heart Disease II survey
- Prospective observational survey (registry)
- multicentre
- 208 European and North African centres
- 6-month follow-up
Authors' conclusion
(i) Valvular heart disease subtype varied between sexes; (ii) concordance with recommended intervention for MS and primary MR was significantly lower for women; and (iii) survival of men and women was similar at 6 months.
Study context
- Population
- Patients with severe native valvular heart disease (VHD) in the VHD II EURObservational Research Programme
- Participants
- 5,219 patients · 208 centres
- Exposure
- Women vs men
- Outcome
- Sex differences in disease characteristics and treatment, including concordance of intervention with class I guideline recommendations (2012 ESC or 2014 AHA/ACC)
Main finding
As reported in the abstract
Concordance with recommended treatment (multivariable regression)
Concordance significantly poorer in women with mitral stenosis (MS) and primary mitral regurgitation (MR)
both P < .001
Observational data: associations, not effects.
Further findings
Concomitant tricuspid intervention
- Similar rate in both sexes, although significant tricuspid regurgitation (TR) significantly more prevalent in women
In-hospital and 6-month survival
- Did not differ between sexes
Original publication
Sex-related differences in severe native valvular heart disease: the ESC-EORP Valvular Heart Disease II survey. Eur Heart J. Published 30 August 2024. doi:10.1093/eurheartj/ehae523
Summarised from the published abstract; every number is checked against it