Aortic & peripheral vascular diseaseCohort study
Sex-related differences in the clinical course of aortic root and ascending aortic aneurysms: the DisSEXion Study
- Retrospective cohort study
- two-centre
Authors' conclusion
In patients having entered a diagnostic programme, involvement of aortic segments and age- and segment-related growth patterns differ between women and men with AscAA, particularly at an older age.
Study context
- Population
- Adults with ascending aortic aneurysm (root and/or ascending ≥40 mm) imaged 2007–2022, Netherlands31.6% female
- Participants
- 1,858 adults
- Exposure
- Female vs male patients with ascending aortic aneurysm
- Outcome
- Male-female differences in aneurysm growth and clinical outcomes
Main finding
As reported in the abstract
Incidence rate ratio
3.4
95% CI 1.5–8.0
P = 0.004
Females vs Males
incidence rate ratio 3.4 (95% CI 1.5–8.0); P = 0.004
- Tubular ascending growth faster in females (corrected for covariates)
- P < 0.001
- Sinuses of Valsalva (SoV) growth faster in males (corrected for covariates)
- P = 0.005
Observational data: associations, not effects.
Further findings
Age at diagnosis
P < 0.001
Segment involvement at diagnosis
Tubular ascending
SoV
Maximum absolute aortic diameter at diagnosis · no difference
P = 0.388
| Outcome | Females | Males | P value |
|---|---|---|---|
| Unadjusted 10-year survival | 72.5% (95% CI 67.8%–77.6%) | 78.3% (95% CI 75.3%–81.3%) | P = 0.010 |
- Segment involvement at diagnosis: tubular P = .030
- Segment involvement at diagnosis: SoV P < .001
Original publication
Sex-related differences in the clinical course of aortic root and ascending aortic aneurysms: the DisSEXion Study. Eur Heart J. Published 26 August 2024. doi:10.1093/eurheartj/ehae525
Summarised from the published abstract; every number is checked against it