Acute cardiac care & resuscitationCohort study
Sex-related disparities in post-cardiac arrest: a cohort study
- prospective registry of consecutive comatose adults
- single centre (Lausanne University Hospital (CHUV))
- multivariable logistic regressions adjusting for cardiac arrest characteristics
Authors' conclusion
Although women presented with worse unadjusted outcomes and more severe prognostic profiles, sex was not independently related to neurological recovery and mortality. Outcome differences likely reflect less favorable underlying cardiac arrest characteristics.
Study context
- Population
- Comatose adults admitted after CA to the Lausanne University Hospital (CHUV) between January 2016 and February 2025, surviving the first 24 hincluded patients (28.6% women, mean age 62 ± 15 years)
- Participants
- 944 adults
- Exposure
- Sex differences in CA characteristics, prognostic indicators, mortality, and long-term neurological outcomes
Main finding
As reported in the abstract
CA characteristics
- women more often presented with non-cardiac etiology and non-shockable rhythm
Observational data: associations, not effects.
Further findings
Favorable neurological outcome (mRS 0-3) · 3 months · unadjusted
P = 0.013
ICU mortality, 3-month mortality, favorable functional outcome (adjusted)
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| sex · ICU mortality; adjusted; comparator not printed · adjusting for cardiac arrest characteristics | 1.08 (0.80–1.46) | ||
| sex · 3-month mortality; adjusted; comparator not printed · adjusting for cardiac arrest characteristics | 1.05 (0.77–1.43) | ||
| sex · adjusting for cardiac arrest characteristics | 1.00 (0.73–1.37) | ||
| 0.512Odds ratio (log scale) |
- ICU mortality, 3-month mortality, favorable functional outcome (adjusted): favorable functional outcome; adjusted; comparator not printed
Prognostic indicators
- They exhibited more malignant EEG patterns, absent SSEP, and higher serum NSE levels
ICU mortality, 3-month mortality, favorable functional outcome (adjusted)
- sex was not independently associated with ICU mortality, 3-month mortality, or favorable functional outcome
Original publication
Sex-related disparities in post-cardiac arrest: a cohort study. Resuscitation. Published 16 April 2026. doi:10.1016/j.resuscitation.2026.111096
Summarised from the published abstract; every number is checked against it