Prevention & lipidsMeta-analysis
Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease
- Genome-wide association meta-analysis with polygenic risk score analysis
- sex-specific analyses
Authors' conclusion
Our findings provide insight into the pleiotropic effects of the RHR variants, contributing towards an improved understanding of mechanisms linking RHR and disease.
Study context
- Population
- Participants of the Trøndelag Health Study (HUNT) and UK Biobank (UKB)HUNT 69,155
- Participants
- 550,467 participants
- Outcome
- Genetic loci associated with resting heart rate (RHR); associations of an RHR PRS with cardiovascular disease (CVD) outcomes
Pooled result
As reported in the abstract
Independent single nucleotide polymorphisms (SNPs) significantly associated with resting heart rate (RHR), total population
403
Independent SNPs significantly associated with RHR, women
253
Independent SNPs significantly associated with RHR, men
167
Original publication
Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease. Eur J Prev Cardiol. Published 4 March 2024. doi:10.1093/eurjpc/zwae092
Summarised from the published abstract; every number is checked against it