Prevention & lipidsCross-sectional study
Sex-specific associations between total cholesterol and non–high-density lipoprotein cholesterol and the presence and extent of coronary artery calcifications
- Cross-sectional study
- pooled cohorts
Authors' conclusion
Total cholesterol was associated with presence of CAC, and non-HDL-Cs were associated with presence and extent of the CAC score in men. No association by total cholesterol or non-HDL-C was found among women.
Study context
- Population
- Adults aged 49–75 years without known cardiovascular disease (CVD) or current lipid-lowering medication, Danish Risk Score study and Danish Cardiovascular Screening Trial cohorts
- Participants
- 10,049 adults
- Exposure
- Women vs men: total cholesterol and non-HDL-C vs coronary artery calcium (CAC) presence and extent
- Womenn = 958
- Menn = 9,091
- Outcome
- CAC presence (CAC > 0) and extent
Main finding
As reported in the abstract
Association of total cholesterol and non-HDL-C with CAC presence and extent, by sex
| Group | CAC presence, total cholesterol: OR (95% CI) | CAC presence, non-HDL-C: OR (95% CI) | CAC extent, total cholesterol: IRR (95% CI) | CAC extent, non-HDL-C: IRR (95% CI) |
|---|---|---|---|---|
| Women | 1.09 (0.94-1.27) | 1.12 (0.96-1.29) | 0.99 (0.83-1.19) | 0.93 (0.78-1.12) |
| Men | 1.26 (1.19-1.33) | 1.25 (1.18-1.33) | 1.04 (0.997-1.07) | 1.04 (1.001-1.08) |
Observational data: associations, not effects.
Original publication
Sex-specific associations between total cholesterol and non–high-density lipoprotein cholesterol and the presence and extent of coronary artery calcifications. Eur J Prev Cardiol. Published 6 February 2025. doi:10.1093/eurjpc/zwaf047
Summarised from the published abstract; every number is checked against it