Cardiometabolic & kidneyCohort study
Sex-specific cardiovascular risk of lower potassium intake in patients with chronic kidney disease (CKD)
- Prospective cohort study
- registry-based
- sex-specific quartiles
Authors' conclusion
Lower estimated potassium intake is associated with a higher risk of CVD in patients with CKD, with a particularly strong association in women.
Study context
- Population
- Patients aged ≥18 years with CKD in Japan (Fukuoka Kidney disease Registry)
- Participants
- 4,314 patients
- Exposure
- Lowest vs highest quartile of estimated potassium intake
- Outcome
- CVD events
- Follow-up
- 5 years
Main finding
CVD, overall cohort
Hazard ratio
1.41
95% CI 0.97–2.03
Lowest quartile vs Highest quartile
HR 1.41 (95% CI 0.97–2.03)
As reported in the abstract
- Patients developing cardiovascular disease (CVD)
- 431
- Men developing CVD
- 292 (12.1%)
- Women developing CVD
- 139 (7.3%)
Observational data: associations, not effects.
Further findings
CVD, sex-stratified (lower vs higher potassium intake) · 5 years
- Men: lower potassium intake, HR
- 0.98 (0.63-1.53) (95% CI)
- Women: lower potassium intake significantly associated with increased CVD risk, HR
- 2.97 (1.44-6.10) (95% CI)
- interaction between sex and potassium intake P < 0.001
Original publication
Sex-specific cardiovascular risk of lower potassium intake in patients with CKD. Eur J Prev Cardiol. Published 17 April 2026. doi:10.1093/eurjpc/zwag226
Summarised from the published abstract; every number is checked against it