Valvular & structural heart diseaseCohort study
Sex-Specific Differences in Upstream Cardiac Damage in Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement (TAVR)
- Prospective registry study
Authors' conclusion
The pattern of cardiac damage secondary to AS differed by sex. In early stages of cardiac damage, women had a lower 5-year mortality than men, whereas in more advanced stages, mortality was comparable between sexes.
Study context
- Population
- Patients with symptomatic aortic stenosis (AS) undergoing TAVR, August 2007–June 2022
- Participants
- 2,026 patients
- Exposure
- Women vs men
- Womenn = 995
- Menn = 1,031reference
- Outcome
- Distribution of cardiac damage stages (0–4) by sex on pre-TAVR echocardiography, and all-cause mortality by stage
- Follow-up
- 5 years
Main finding
As reported in the abstract
Cardiac damage stage distribution
Stage 0
Stage 1
Stage 2
Stage 3
Stage 4
Observational data: associations, not effects.
Further findings
| Outcome | adjusted HR (95% CI) | |
|---|---|---|
| 5-year all-cause mortality per stage increase (linear trend) · 5 years — Women · for linear trend | 1.43 (1.28–1.60) | |
| 5-year all-cause mortality per stage increase (linear trend) · 5 years — Men · for linear trend | 1.26 (1.14–1.38) | |
| 0.512Adjusted hazard ratio (log scale) |
5-year mortality, women vs men, by stage
- Female sex associated with lower 5-year mortality in early stages (0, 1 or 2) but not in advanced stages (3 or 4)
Original publication
Sex-Specific Differences in Upstream Cardiac Damage in Patients With Aortic Stenosis Undergoing TAVR. JACC Cardiovasc Interv. Published 27 May 2024. doi:10.1016/j.jcin.2024.03.031
Summarised from the published abstract; every number is checked against it