Heart failure & cardiomyopathies
Sex-Specific Impairment of Cardiac Functional Reserve in Heart Failure with Preserved Ejection Fraction (HFpEF): Insights From the HFpEF Stress Trial
Authors' conclusion
Women with HFpEF demonstrate sex-specific functional alterations of right ventricular, left atrial, and left ventricular function during exercise stress.
Study context
- Population
- Patients with exertional dyspnoea, preserved ejection fraction (EF) (≥50%) and signs of diastolic dysfunction; HFpEF or noncardiac dyspnoea diagnosed by right heart catheterization (RHC)75 recruited
- Participants
- 68 patients
- Exposure
- Women vs men with HFpEF
- Femalesn = 44
- Malesn = 24reference
- Outcome
- Sex-specific differences in HFpEF during exercise stress
- Follow-up
- Exercise stress
Methodological detailsrest and exercise stress RHC, echocardiography and CMR
- Rest and exercise stress RHC, echocardiography and CMR
Main finding
As reported in the abstract
| Group | RV stroke volume | Change in left atrial EF, rest to exercise | LV filling |
|---|---|---|---|
| Females | 38.1 mL/m² BSA | −2.7% | 35.5 mL/m² BSA |
| Males | 50.4 mL/m² BSA | 2.5% | 44.2 mL/m² BSA |
RV stroke volume
Females38.1 mL/m² BSA
Males50.4 mL/m² BSA
Change in left atrial EF, rest to exercise
Females−2.7%
Males2.5%
LV filling
Females35.5 mL/m² BSA
Males44.2 mL/m² BSA
- Females vs Males: P = 0.011 — RV stroke volume
- Females vs Males: P = 0.020 — change in left atrial EF
- Females vs Males: P = 0.017 — LV filling
Observational data: associations, not effects.
Further findings
Sex-specific differences in noncardiac dyspnoea
- These sex-specific differences were not present in noncardiac dyspnea
Original publication
Sex-Specific Impairment of Cardiac Functional Reserve in HFpEF: Insights From the HFpEF Stress Trial. JACC Adv. Published 24 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →