Prevention & lipidsCohort study
Sex-specific lifetime risk of cardiovascular events: the European Prospective Investigation into Cancer-Norfolk prospective population cohort study
- Prospective population cohort study
- population-based
- median follow-up 26.2 years
Authors' conclusion
Men had substantially higher risk of incident CVD and CV mortality than women, which was attenuated amongst people with prevalent CVD.
Study context
- Population
- Participants of the European Prospective Investigation into Cancer-Norfolk, with and without prevalent cardiovascular disease (CVD)54.5% women
- Participants
- 23,859 participants
- Exposure
- Men vs women
- Outcome
- Sex-specific lifetime risks of incident CVD and CV mortality (accounting for competing risk of death)
- Follow-up
- At age 75
Main finding
As reported in the abstract
Incident CVD and CV mortality (adjusted lifetime risk)
Men
69.1%
Incident CVD · CV mortality 4.4%
Women
57.7%
Incident CVD · CV mortality 3.1%
Men vs WomenCause-specific hazard ratio (99% CI)
incident CVD
1.49(1.41–1.57)
CV mortality
1.42(1.31–1.54)
Observational data: associations, not effects.
Further findings
First CVD presentation
- MI was the predominant first presentation in men until the eighth decade
- In women, first CVD manifestations after the sixth decade were predominantly AF and stroke
Incident CVD and CV mortality in people with prevalent CVD (subgroup)
- Male-associated excess relative risks halved in people with prevalent CVD
Original publication
Sex-specific lifetime risk of cardiovascular events: the European Prospective Investigation into Cancer-Norfolk prospective population cohort study. Eur J Prev Cardiol. Published 30 November 2023. doi:10.1093/eurjpc/zwad283
Summarised from the published abstract; every number is checked against it