Valvular & structural heart diseaseCohort study
Sex-Specific Outcomes in Patients Undergoing Mitral Valve Transcatheter Edge-to-Edge Repair
- investigator-initiated, multicenter M-TEER registry
Authors' conclusion
PASCAL M-TEER resulted in similar technical success rates and 1-year mortality across sexes, despite females achieving an optimal result less frequently, due to higher postprocedural gradients. MR reduction to mild or less was the primary determinant of improved survival, consistent across sexes.
Study context
- Population
- Patients with mitral regurgitation undergoing PASCAL M-TEERfemales 1,150 · males 1,451
- Participants
- 2,601 patients
- Exposure
- Females vs males undergoing PASCAL M-TEER
- femalesn = 1,150
- malesn = 1,451
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Optimal result (residual MR ≤ 1+ and mean transmitral pressure gradient <5 mm Hg) · discharge
Mean transmitral valve pressure gradient ≥5 mm Hg
Residual mild or less MR
MR etiology distribution
primary
secondary
mixed
| Outcome | females | males |
|---|---|---|
| All-cause mortality · 1 year | 11.0% (95% CI 8.7%–13.2%) | 12.1% (95% CI 10.1%–14.1%) |
- Optimal result (residual mitral regurgitation (MR) ≤ 1+ and mean transmitral pressure gradient <5 mm Hg): P < 0.001
- Mean transmitral valve pressure gradient ≥5 mm Hg: P < 0.001
- Residual mild or less MR: P = 0.066
- All-cause mortality: P = 0.266
- MR etiology distribution: P = 0.219
Predictors of 1-year mortality
- Residual mild or less MR, adjusted HR (95% CI: 0.38-0.84; P = 0.005)
- 0.57
- Gradients <5 mm Hg, adjusted HR (95% CI: 0.40-1.01; P = 0.056)
- 0.63
Original publication
Summarised from the published abstract; every number is checked against it