Valvular & structural heart diseaseCohort study
Sex-specific patterns of valvulo-aortopathy in bicuspid aortic valve according to the international consensus framework: insights from the RE-BAV registry
- registry
Authors' conclusion
Sex-related differences in BAV involved aortopathy phenotype, aortic regurgitation burden, and proximal aortic dimensions. Interpretation of proximal aortic dimensions depended on the normalization strategy used, indicating that indexing methods should not be treated as interchangeable.
Study context
- Population
- Adults with bicuspid aortic valve (BAV) from the RE-BAV registry588 men
- Participants
- 808 adults
- Exposure
- Women vs men
- menn = 588
Main finding
As reported in the abstract
- Valve morphology distribution did not differ by sex
Observational data: associations, not effects.
Further findings
Extended phenotype · more frequent in women
P = 0.001
Root phenotype · more common in men
P = 0.006
Moderate-to-severe aortic regurgitation · more prevalent in men
P < 0.001
Ascending aorta indexed to body surface area · larger values in women
P = 0.001
Cross-sectional area-to-height ratio at the sinuses of Valsalva · higher in men · remained higher in men across proximal segments
P < 0.001
Prevalence of aortic dilatation
- prevalence of aortic dilatation was similar
Ascending aorta indexed to body surface area
- diameter/height showed no sex-related difference at this level
Age and proximal aortic dimensions
- Age was independently associated with larger proximal aortic dimensions across all strategies
Original publication
Summarised from the published abstract; every number is checked against it