Valvular & structural heart diseaseResearch article
Sex-Specific Prognostic Value of Aortic Valve Calcium and the Risk for Aortic Stenosis: Multi-Ethnic Study of Atherosclerosis (MESA)
- Multi-Ethnic Study of Atherosclerosis (MESA)
- multivariable-adjusted Cox proportional hazards regression
- median follow-up of 16 years
Authors' conclusion
The association of AVC with the long-term risk of incident AS was similar for women and men, further supporting the utility of AVC as a prognostic marker for incident AS.
Study context
- Population
- MESA participants with aortic valve calcium (AVC) measured using cardiac computed tomographyMESA participants with AVC measured, women comprised 52.9%
- Participants
- 6,810 participants
- Comparison
- whether the association of AVC with the long-term risk of clinically significant aortic stenosis (AS) differed for women compared with men
Main finding
As reported in the abstract
AVC >0 present
Further findings
| Outcome | Women | Men |
|---|---|---|
| Incident AS cases · median follow-up of 16 years | 65 events | 75 events |
| Incident AS per AVC as a continuous variable (ln [AVC+1]) | ||
| hazard ratio (95% CI) | 1.91 (1.68-2.16) | 2.13 (1.88-2.41) |
| Incident AS, AVC ≥300 | ||
| hazard ratio (95% CI) | 134.9 (45.1-403.9) | 132.8 (6.2-274.9) |
- Incident AS per AVC as a continuous variable (ln [AVC+1]) — No interaction between AVC and sex
- P =0.31
- Incident AS per AVC as a continuous variable (ln [AVC+1]): interaction P =0.31
Incident AS, AVC ≥300
- Women and men had similar adjusted hazards for incident AS across AVC categories
Original publication
Sex-Specific Prognostic Value of Aortic Valve Calcium and the Risk for Aortic Stenosis: Multi-Ethnic Study of Atherosclerosis (MESA). Circ Cardiovasc Imaging. Published 9 April 2026. doi:10.1161/circimaging.125.018849
Summarised from the published abstract; every number is checked against it