Cohort study
Sex-specific risk factors for new-onset heart failure: the PREVEND study at 25 years
- Prospective community-based cohort study
- 25 years of follow-up
Authors' conclusion
In this European cohort, the lifetime risk of developing HFrEF was greater in men than in women, while women were at greater risk of developing HFpEF. Eight directly and indirectly modifiable risk factors substantially accounted for the risk of developing HFrEF and HFpEF, particularly in women.
Study context
- Population
- European community-based cohort (PREVEND), baseline from 1997, followed until 2022804 new-onset HF cases
- Participants
- 8,558 participants
- Exposure
- Women vs men
- Outcome
- Sex-specific lifetime risk of new-onset HFrEF (EF < 50%) and HFpEF (EF ≥ 50%), and population attributable fraction of modifiable risk factors
- Follow-up
- 25 years
Main finding
As reported in the abstract
Overall HF
HFrEF
HFpEF
Observational data: associations, not effects.
Further findings
Population attributable fraction of 8 risk factors (hypertension, hypercholesterolaemia, obesity, smoking, AF, CKD, MI, DM)
HFrEF
HFpEF
Mean age at HF onset
Population attributable fraction of 8 risk factors (hypertension, hypercholesterolaemia, obesity, smoking, AF, CKD, MI, DM)
- Strongest risk factors in both sexes: hypertension and hypercholesterolaemia for HFrEF; hypertension and obesity for HFpEF
Original publication
Summarised from the published abstract; every number is checked against it