Coronary disease & ACSCohort study
Sex-Specific Trends in Acute Myocardial Infarction Within an Integrated Healthcare Network, 2000 Through 2014
- Retrospective cohort study
- integrated healthcare delivery system
Authors' conclusion
These results suggest that the incidence of hospitalized AMI declined between 2000 and 2014; however, declines in AMI have slowed among women in comparison with men in recent years.
Study context
- Population
- Members ≥35 years of age in Kaiser Permanente Southern California, 2000–201445,331 acute myocardial infarction (AMI) hospitalizations
- Exposure
- Women vs men
- Outcome
- Temporal trends in incident hospitalized AMI (age- and sex-standardized incidence per 100 000 person-years; AAPC)
- Follow-up
- 2000 through 2014
Main finding
As reported in the abstract
Age- and sex-standardized AMI incidence rate
- AMI incidence 2000
- 322.4 (per 100 000 person-years; 95% CI 311.0-333.9)
- AMI incidence 2014
- 174.6 (per 100 000 person-years; 95% CI 168.2-181.0)
- AAPC overall
- −4.4% (95% CI −4.2 to −4.6)
- Period percent change
- −46.6%
- AAPC women 2000–2009
- −4.6% (95% CI −4.1 to −5.2)
- AAPC women 2010–2014
- −2.3% (95% CI −1.2 to −3.4)
- AAPC men, stable over study period
- −4.7% (95% CI −4.4 to −4.9)
Observational data: associations, not effects.
Further findings
STEMI hospitalization
- AAPC overall
- −8.3% (95% CI −8.0% to −8.6%)
- AAPC women 2000–2009
- −10.2% (95% CI −9.3 to −11.1)
- AAPC women 2010–2014
- −5.2% (95% CI −3.1 to −7.3)
- AAPC men, stable
- −8.0% (95% CI −7.6 to −8.4)
NSTEMI hospitalization
- AAPC women
- −1.9% (95% CI −1.5 to −2.3)
- AAPC men
- −2.8% (95% CI −2.5 to −3.2)
- smaller than for STEMI among both women and men
Original publication
Sex-Specific Trends in Acute Myocardial Infarction Within an Integrated Healthcare Network, 2000 Through 2014. Circulation. Published 17 February 2020. doi:10.1161/circulationaha.119.044738
Summarised from the published abstract; every number is checked against it