Coronary disease & ACSCohort study
Sex-specific V̇O2peak reference values and their association with major adverse cardiovascular events in Norwegian cardiac rehabilitation patients
- Retrospective cohort study
Authors' conclusion
This study provides novel sex- and diagnosis-specific V̇O2peak reference values for Norwegian CAD patients and confirms V̇O2peak as a strong prognostic marker
Study context
- Population
- Coronary artery disease (CAD) patients attending inpatient cardiac rehabilitation in Norway (2004–2022), by index event: Myocardial infarction (MI), coronary artery bypass grafting (CABG) or PCI/CAD21% women
- Participants
- 1,651 patients
- Exposure
- V̇O2peak by sex and diagnosis, and its association with MACE
- Outcome
- Sex-specific V̇O2peak reference values and association of V̇O2peak with MACE (all-cause mortality, ACS, stroke or HF)
Main finding
As reported in the abstract
V̇O2peak and MACE
Hazard ratio (95% CI)
Men
0.93(0.92–0.95)
Women
0.95(0.91–0.99)
Per 1 mL·kg-1·min-1 higher V̇O2peak, as printed
- MACE during 7880 person-years
- 510 patients (36%)
- Highest vs lowest cardiorespiratory fitness quartile: lower MACE risk
- 55%
Observational data: associations, not effects.
Further findings
V̇O2peak by index event
- Highest after previous MI, followed by CABG and PCI/CAD
- P < 0.001
- Associations with MACE consistent across CAD subcategories
Original publication
Sex-specific V̇O2peak reference values and their association with major adverse cardiovascular events in Norwegian cardiac rehabilitation patients. Eur J Prev Cardiol. Published 8 April 2026. doi:10.1093/eurjpc/zwag194
Summarised from the published abstract; every number is checked against it