Heart failure & cardiomyopathiesCohort study
Short- and long-term mortality in patients hospitalized for dyspnoea with acute heart failure, respiratory infection, or both: insights from the PARADISE cohort
- Cohort study
Authors' conclusion
Patients with concomitant AHF and RI showed an increased in-hospital risk but no excess post-discharge risk compared with AHF alone, whereas RI alone is not associated with increased mortality both in-hospital and post-discharge.
Study context
- Population
- Patients hospitalised for acute dyspnoea discharged with acute heart failure (AHF), respiratory infection or both (PARADISE cohort)
- Participants
- 11,679 patients
- Exposure
- AHF + respiratory infection (RI) or RI alone vs AHF alone
- AHF alonen = 4,349reference
- RI alonen = 5,091
- AHF and RIn = 2,239
- Outcome
- In-hospital and post-discharge mortality
Main finding
As reported in the abstract
Each group vs AHF aloneEstimate (CI)P value
AHF and RIin-hospital mortality
aOR 1.62(1.33–1.98)
P < 0.001AHF and RIpost-discharge mortality
aHR 0.99(0.88–1.11)
P = 0.9RI alonein-hospital mortality
aOR 1.11(0.89–1.39)
P = 0.3RI alonepost-discharge mortality
aHR 1.07(0.97–1.17)
P = 0.2- In-hospital mortality highest with concomitant AHF and RI
- 21.9%
- Post-discharge mortality highest with AHF
- 55.2%
Observational data: associations, not effects.
Further findings
Sensitivity analyses including natriuretic peptides
- Confirm the main results
Original publication
Short- and long-term mortality in patients hospitalized for dyspnoea with acute heart failure, respiratory infection, or both: insights from the PARADISE cohort. Eur J Heart Fail. Published 10 May 2026. doi:10.1093/ejhf/xuag160
Summarised from the published abstract; every number is checked against it